SLC33A1

Across TCGA patient cohorts, SLC33A1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC33A1-associated genes across cancer lineages are c-Met_pY1235, MSH2, and p27_pT198. Each is linked with SLC33A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC33A1-to-partner and partner-to-SLC33A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by SLC33A1-low versus SLC33A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC33A1→partner) and Y-score (partner→SLC33A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.082	+1.916	.002	.009	3	3
UCEC	MSH2 →	-0.174	-2.558	.036	.010	3	2
UCEC	p27_pT198 →	+0.107	+2.115	.005	.017	3	2
UCEC	ASNS →	+0.363	+1.584	.005	.019	3	2
UCEC	ATM →	-0.509	-2.321	.001	.001	3	2
UCEC	Cyclin-E2 →	+0.184	+1.925	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

c-Met_pY1235 by SLC33A1 expression — UCEC

Explore this box plot interactively →