SLC32A1

Across TCGA pan-cancer cohorts, SLC32A1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated SLC32A1 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SLC32A1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC32A1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

SKCM, SCLC, and PAAD are the cancer types where SLC32A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.351	0.207	<.001	94	view →
SCLC	OS	Median	III,IV	0.833	0.380	.001	33	view →
PAAD	DFS	Tertile	All	0.456	0.208	<.001	31	view →
LUAD	DFS	Median	II,III,IV	0.612	0.375	.014	28	view →
BRCA	DFS	Tertile	II,III,IV	0.629	0.482	.030	16	view →
ACC	DFS	Tertile	All	0.202	0.536	.031	15	view →
HNSC	DFS	Tertile	All	0.446	0.298	.019	11	view →
STAD	DFS	Quartile	IV	0.380	0.973	.019	10	view →
THCA	DFS	Tertile	IV	0.075	0.807	<.001	9	view →
LGG	DFS	Quartile	All	0.556	0.308	.011	9	view →
CHOL	DFS	Quartile	II,III,IV	1.000	0.215	.020	6	view →
THYM	OS	Median	II,III,IV	0.931	0.709	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SLC32A1–SKCM (DFS)

Open the SKCM breakdown →