SLC31A1

Across TCGA pan-cancer cohorts, SLC31A1 mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated SLC31A1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SLC31A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC31A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, PDAC, and GBM are the cancer types where SLC31A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.918	1.000	.017	72	view →
PDAC	DFS	Tertile	III,IV	0.363	0.865	.001	38	view →
GBM	DFS	Tertile	All	0.264	0.509	<.001	31	view →
CCRCC	DFS	Median	All	0.915	0.517	.001	23	view →
UCEC	DFS	Tertile	II,III,IV	0.182	1.000	.038	12	view →
HNSC	DFS	Quartile	All	0.845	0.521	.017	7	view →
OV	DFS	Median	All	0.845	1.000	.041	4	view →
LSCC	OS	Median	All	0.907	1.000	.016	2	view →
LUAD	DFS	Quartile	II,III,IV	0.757	0.369	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SLC31A1–COAD (DFS)

Open the COAD breakdown →