SLC30A4

Across TCGA patient cohorts, SLC30A4 mutation is significantly associated with the RNA expression of many other genes, with 175 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC30A4-associated genes across cancer lineages are DEFB127, RNY1P1, and PRLH. Each is linked with SLC30A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC30A4-to-partner and partner-to-SLC30A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB127 grouped by SLC30A4-low versus SLC30A4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC30A4→partner) and Y-score (partner→SLC30A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DEFB127 →	+0.152	+5.505	<.001	.004	3	2
UCEC	RNY1P1 →	+0.314	+3.920	<.001	.001	3	2
HNSC	PRLH →	+0.183	+5.822	<.001	.003	3	1
SKCM	RBM22P12 →	+0.015	+3.858	<.001	.001	3	1
SKCM	MIR3156-2 →	+0.181	+3.372	.004	.005	3	1
SKCM	MIR5192 →	+0.321	+2.501	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 175 associations by consensus.

DEFB127 by SLC30A4 expression — HNSC

Explore this box plot interactively →