SLC30A4

Across TCGA patient cohorts, SLC30A4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC30A4-associated genes across cancer lineages are Heregulin, Akt_pT308, and Rab25. Each is linked with SLC30A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC30A4-to-partner and partner-to-SLC30A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by SLC30A4-low versus SLC30A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC30A4→partner) and Y-score (partner→SLC30A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.216	-3.000	.002	.037	3	1
UCEC	Akt_pT308 →	+0.855	+3.000	.018	.037	3	1
UCEC	Rab25 →	-0.551	-3.000	.004	.037	3	1
UCEC	eEF2 →	+0.465	+3.000	.024	.037	2	1
UCEC	NF2 →	+0.290	+3.000	.020	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Heregulin by SLC30A4 expression — UCEC

Explore this box plot interactively →