SLC30A2

Across TCGA cell cohorts, SLC30A2 mutation is significantly associated with the mutation status of many other genes, with 384 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC30A2-associated genes across cancer lineages are CUL3, U2AF1, and KLKB1. Each is linked with SLC30A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC30A2-to-partner and partner-to-SLC30A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUL3 grouped by SLC30A2-low versus SLC30A2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC30A2→partner) and Y-score (partner→SLC30A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CUL3 →	+4.339	+4.339	.009	.009	1	2
LUNG_NSCLC_LUAD	U2AF1 →	+4.339	+5.303	<.001	<.001	1	2
LUNG_NSCLC_LUAD	KLKB1 →	+4.339	+4.339	.009	.009	1	2
BLOOD_Lymphoma	AKAP1 →	+5.584	+5.014	.003	.003	1	2
LARGE_INTESTINE	ADAMTS10 →	+2.043	+3.693	.009	.009	1	2
BLOOD_Lymphoma	TTBK1 →	+4.584	+4.584	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 384 associations by consensus.

CUL3 by SLC30A2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →