SLC2A8

Across TCGA pan-cancer cohorts, SLC2A8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLC2A8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC2A8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC2A8 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where SLC2A8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC2A8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.349	<.001	11	view →
THCA	Male	III,IV	−1.035	<.001	11	view →
HNSC	Male	III,IV	+0.922	<.001	11	view →
BLCA	Male	IV	−2.457	<.001	8	view →
LIHC	Female	All	+0.529	<.001	6	view →
STAD	Male	II,III,IV	+0.664	.002	4	view →
LUSC	All	All	+0.356	.001	3	view →
KIRC	Female	All	+0.371	.012	2	view →
PRAD	All	All	−0.269	<.001	2	view →
LUAD	Female	II,III,IV	−0.231	.006	2	view →
KICH	Female	II,III,IV	+0.958	.033	1	view →
ESCA	All	All	+0.712	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLC2A8–COAD

Open the COAD breakdown →