SLC2A8

Across TCGA pan-cancer cohorts, SLC2A8 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SLC2A8’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SLC2A8 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SLC2A8 is over-expressed in tumor, although a few such as LSCC and CCRCC show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where SLC2A8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC2A8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.425	<.001	7	view →
CCRCC	All	III,IV	−0.257	.003	6	view →
LUAD	All	All	+0.161	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SLC2A8–LSCC

Open the LSCC breakdown →