SLC2A6

Across TCGA patient cohorts, SLC2A6 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC2A6-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ERK2. Each is linked with SLC2A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC2A6-to-partner and partner-to-SLC2A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SLC2A6-low versus SLC2A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC2A6→partner) and Y-score (partner→SLC2A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.093	-1.847	.011	.049	3	2
UCEC	A-Raf_pS299 →	-0.128	-3.584	.003	.002	3	2
UCEC	ERK2 →	+0.249	+1.847	<.001	.008	3	2
UCEC	ACC1 →	+0.298	+3.013	.026	.018	3	2
UCEC	PDCD4 →	-0.593	-2.247	<.001	.001	3	2
UCEC	Shc_pY317 →	-0.227	-2.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

14-3-3_beta by SLC2A6 expression — UCEC

Explore this box plot interactively →