SLC2A6

Across TCGA cell cohorts, SLC2A6 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC2A6-associated genes across cancer lineages are SH3GL2, DDX25, and TAFA1. Each is linked with SLC2A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC2A6-to-partner and partner-to-SLC2A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by SLC2A6-low versus SLC2A6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC2A6→partner) and Y-score (partner→SLC2A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.065	+3.252	.008	.009	3	1
LARGE_INTESTINE	DDX25 →	+0.099	+3.254	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	BPIFA1 →	+0.098	+2.688	.008	.008	3	1
CNS	DEFA4 →	+0.106	+4.754	<.001	.005	3	1
CNS	HELT →	+0.027	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SH3GL2 by SLC2A6 expression — LARGE_INTESTINE

Explore this box plot interactively →