SLC2A4

Across TCGA patient cohorts, SLC2A4 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC2A4-associated genes across cancer lineages are ERK2, Annexin-1, and VEGFR2. Each is linked with SLC2A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC2A4-to-partner and partner-to-SLC2A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SLC2A4-low versus SLC2A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC2A4→partner) and Y-score (partner→SLC2A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.144	+1.584	.019	.034	3	2
UCEC	Annexin-1 →	+0.636	+3.999	<.001	<.001	3	2
UCEC	VEGFR2 →	+0.233	+1.302	.014	.015	3	2
UCEC	14-3-3_beta →	-0.106	-1.973	<.001	.008	3	1
UCEC	eEF2 →	+0.295	+2.700	.009	.005	3	1
UCEC	A-Raf_pS299 →	-0.097	-1.584	.011	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ERK2 by SLC2A4 expression — UCEC

Explore this box plot interactively →