SLC2A12

Across TCGA patient cohorts, SLC2A12 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC2A12-associated genes across cancer lineages are Shc_pY317, ATM, and EGFR_pY1068. Each is linked with SLC2A12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC2A12-to-partner and partner-to-SLC2A12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by SLC2A12-low versus SLC2A12-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC2A12→partner) and Y-score (partner→SLC2A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Shc_pY317 →	-0.206	-2.304	.029	.035	3	2
UCEC	ATM →	-0.429	-3.446	.007	.005	3	2
UCEC	EGFR_pY1068 →	-0.280	-2.392	.001	<.001	3	1
UCEC	eIF4E →	+0.206	+2.598	.005	.005	3	1
UCEC	A-Raf_pS299 →	-0.132	-2.115	.001	.017	3	1
UCEC	ERK2 →	+0.156	+2.459	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Shc_pY317 by SLC2A12 expression — SKCM

Explore this box plot interactively →