SLC2A1

Across TCGA pan-cancer cohorts, SLC2A1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SLC2A1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC2A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC2A1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where SLC2A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC2A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+3.112	<.001	12	view →
KIRC	Female	IV	+2.360	<.001	12	view →
LUAD	Male	III,IV	+4.640	<.001	11	view →
COAD	Male	IV	+2.067	<.001	11	view →
LUSC	Male	III,IV	+5.732	<.001	9	view →
KICH	Female	II,III,IV	−2.432	<.001	7	view →
LIHC	All	II,III,IV	+1.007	<.001	7	view →
BLCA	Male	III,IV	+3.157	.016	6	view →
UCEC	All	III,IV	+2.288	<.001	6	view →
BRCA	All	III,IV	+1.416	<.001	6	view →
STAD	All	All	+1.568	<.001	5	view →
THCA	Male	All	+0.587	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SLC2A1–HNSC

Open the HNSC breakdown →