Across TCGA pan-cancer cohorts, SLC29A3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SLC29A3 data layer compared with 2 for mutation status and 3 for mass-spec protein.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SLC29A3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC29A3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and DLBC show a favorable association.
LIHC, SKCM, and DLBC are the cancer types where SLC29A3 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.