SLC28A1

Across TCGA patient cohorts, SLC28A1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC28A1-associated genes across cancer lineages are MEK1, Notch1, and p62 Lck ligand. Each is linked with SLC28A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC28A1-to-partner and partner-to-SLC28A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLC28A1-low versus SLC28A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC28A1→partner) and Y-score (partner→SLC28A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.298	+2.700	.034	.006	3	2
UCEC	Notch1 →	+0.181	+2.013	<.001	.016	3	2
SKCM	p62 Lck ligand →	+0.638	+2.472	<.001	.010	3	2
UCEC	Annexin_VII →	-0.129	-3.169	.015	.018	3	2
UCEC	STAT3_pY705 →	-0.289	-1.678	.004	.023	3	2
UCEC	ASNS →	+0.423	+1.678	.002	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MEK1 by SLC28A1 expression — UCEC

Explore this box plot interactively →