SLC27A6

Across TCGA pan-cancer cohorts, SLC27A6 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC27A6 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SLC27A6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC27A6 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, PRAD, and SKCM are the cancer types where SLC27A6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
PRAD	DFS	Median	All	0.617	0.886	.029	6	view →
SKCM	DFS	Median	III,IV	0.190	0.680	<.001	6	view →
UCEC	DFS	Median	II,III,IV	0.844	0.303	.023	6	view →
LUAD	DFS	Median	II,III,IV	0.098	0.651	.001	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC27A6–LUSC (DFS)

Open the LUSC breakdown →