SLC27A5

Across TCGA pan-cancer cohorts, SLC27A5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC27A5 data layer compared with 7 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher SLC27A5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC27A5 expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, HNSC, and LIHC are the cancer types where SLC27A5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.768	0.433	<.001	93	view →
HNSC	OS	Tertile	IV	0.519	0.270	.001	71	view →
LIHC	OS	Quartile	All	0.783	0.558	<.001	58	view →
ACC	DFS	Tertile	All	0.142	0.702	.005	33	view →
ESCA	DFS	Median	III,IV	0.322	0.540	.009	31	view →
STAD	DFS	Tertile	IV	0.232	0.632	.008	24	view →
UCS	DFS	Median	II,III,IV	0.438	0.180	.014	16	view →
LUSC	DFS	Tertile	All	0.820	0.706	.002	14	view →
BLCA	DFS	Tertile	IV	0.481	0.230	.002	13	view →
UCEC	DFS	Quartile	II,III,IV	0.675	0.857	.012	12	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	10	view →
CHOL	DFS	Quartile	II,III,IV	0.157	0.779	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC27A5–UVM (DFS)

Open the UVM breakdown →