SLC27A5

Across TCGA pan-cancer cohorts, SLC27A5 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC27A5 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SLC27A5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC27A5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

CESC, STAD, and DLBC are the cancer types where SLC27A5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.190	0.790	<.001	30	view →
STAD	OS	Median	All	0.001	0.667	<.001	30	view →
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
PRAD	DFS	Median	All	0.110	0.776	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	II,III,IV	0.924	0.667	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC27A5–CESC (DFS)

Open the CESC breakdown →