SLC27A4

Across TCGA pan-cancer cohorts, SLC27A4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SLC27A4 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC27A4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SLC27A4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where SLC27A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.893	0.589	.003	44	view →
CCRCC	OS	Median	All	0.956	0.748	.004	21	view →
LUAD	OS	Tertile	II,III,IV	0.328	1.000	.002	20	view →
UCEC	OS	Tertile	III,IV	1.000	0.290	.042	8	view →
GBM	DFS	Quartile	All	0.937	0.667	.001	7	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SLC27A4–HNSC (OS)

Open the HNSC breakdown →