SLC27A4

Across TCGA pan-cancer cohorts, SLC27A4 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SLC27A4’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SLC27A4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SLC27A4 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, LSCC, and COAD are the cancer types where SLC27A4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC27A4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−0.649	<.001	12	view →
LSCC	Male	All	+0.183	<.001	4	view →
COAD	All	II,III,IV	−0.078	.041	2	view →
HNSC	Male	All	−0.183	.025	1	view →
LUAD	Male	III,IV	−0.129	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SLC27A4–CCRCC

Open the CCRCC breakdown →