SLC27A4

Across TCGA patient cohorts, SLC27A4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC27A4-associated genes across cancer lineages are Src_pY527, ETS-1, and JNK_pT183_Y185. Each is linked with SLC27A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC27A4-to-partner and partner-to-SLC27A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by SLC27A4-low versus SLC27A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC27A4→partner) and Y-score (partner→SLC27A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.503	-3.311	.004	.010	3	3
UCEC	ETS-1 →	+0.258	+3.169	.049	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.194	-2.584	.005	.010	3	1
UCEC	JNK2 →	+0.182	+2.321	.026	.006	3	1
UCEC	MEK1 →	+0.363	+2.000	.016	.030	3	1
UCEC	MSH6 →	-0.650	-2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Src_pY527 by SLC27A4 expression — UCEC

Explore this box plot interactively →