SLC27A1

Across TCGA pan-cancer cohorts, SLC27A1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SLC27A1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC27A1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SLC27A1 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where SLC27A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC27A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.335	<.001	11	view →
LSCC	Female	II,III,IV	−0.521	<.001	9	view →
HNSC	All	III,IV	−0.396	<.001	9	view →
CCRCC	Female	All	+0.265	<.001	9	view →
LUAD	Male	All	−0.261	<.001	8	view →
PDAC	All	II,III,IV	+0.257	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SLC27A1–COAD

Open the COAD breakdown →