SLC26A8

Across TCGA patient cohorts, SLC26A8 mutation is significantly associated with the RNA expression of many other genes, with 2,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A8-associated genes across cancer lineages are FANCE, GPATCH3, and DMPK. Each is linked with SLC26A8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC26A8-to-partner and partner-to-SLC26A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCE grouped by SLC26A8-low versus SLC26A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A8→partner) and Y-score (partner→SLC26A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCE →	+0.476	+2.928	.001	<.001	3	3
UCEC	GPATCH3 →	+0.285	+1.638	.003	.001	3	3
SKCM	DMPK →	+0.391	+1.353	.004	.003	3	3
UCEC	COMMD4 →	+0.453	+1.818	<.001	<.001	3	3
CESC	RNU4-36P →	+0.229	+3.556	.004	.002	3	2
CESC	RN7SKP140 →	+0.068	+4.516	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,718 associations by consensus.

FANCE by SLC26A8 expression — UCEC

Explore this box plot interactively →