SLC26A8

Across TCGA patient cohorts, SLC26A8 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A8-associated genes across cancer lineages are 4E-BP1, Notch1, and Src. Each is linked with SLC26A8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC26A8-to-partner and partner-to-SLC26A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SLC26A8-low versus SLC26A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A8→partner) and Y-score (partner→SLC26A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.329	+3.906	<.001	<.001	3	3
UCEC	Notch1 →	+0.131	+2.920	.004	<.001	3	2
UCEC	Src →	-0.175	-1.678	.008	.021	3	2
UCEC	Caspase-7-cleavedD198 →	+0.621	+1.945	.001	.002	3	2
SKCM	Rictor_pT1135 →	+0.130	+1.660	.006	.001	3	2
UCEC	EGFR_pY1068 →	-0.216	-1.678	.008	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

4E-BP1 by SLC26A8 expression — UCEC

Explore this box plot interactively →