SLC26A8

Across TCGA cell cohorts, SLC26A8 mutation is significantly associated with the RNA expression of many other genes, with 524 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC26A8-associated genes across cancer lineages are SPINK9, ADAM7, and OR5M8. Each is linked with SLC26A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC26A8-to-partner and partner-to-SLC26A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by SLC26A8-low versus SLC26A8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A8→partner) and Y-score (partner→SLC26A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPINK9 →	+0.181	+2.278	<.001	.003	3	2
BLOOD_Leukemia	ADAM7 →	+0.016	+3.507	<.001	.004	3	2
CNS	OR5M8 →	+0.013	+4.169	<.001	.008	3	1
CNS	OR13C2 →	+0.011	+4.169	<.001	.008	3	1
LARGE_INTESTINE	ANKRD54 →	+0.654	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	POLDIP3 →	+0.644	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 524 associations by consensus.

SPINK9 by SLC26A8 expression — LARGE_INTESTINE

Explore this box plot interactively →