Across TCGA patient cohorts, SLC26A6 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A6-associated genes across cancer lineages are p62 Lck ligand, Caspase-7-cleavedD198, and Caspase-8. Each is linked with SLC26A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC26A6-to-partner and partner-to-SLC26A6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A6→partner) and Y-score (partner→SLC26A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.384	+2.321	.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.645	+1.584	.002	.019	3	2
UCEC	Caspase-8 →	-0.250	-2.388	.005	.002	3	2
UCEC	eIF4E →	+0.182	+1.584	.016	.019	3	1
UCEC	Gab2 →	+0.263	+2.700	.040	.006	3	1
UCEC	IGFBP2 →	-0.724	-1.906	.001	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

SLC26A6 survival (RNA) · tumor vs normal (RNA) · all SLC26A6 data types