SLC26A4

Across TCGA patient cohorts, SLC26A4 mutation is significantly associated with the RNA expression of many other genes, with 5,564 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A4-associated genes across cancer lineages are SKA1, SGO2, and GRPEL2. Each is linked with SLC26A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC26A4-to-partner and partner-to-SLC26A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by SLC26A4-low versus SLC26A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A4→partner) and Y-score (partner→SLC26A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.852	+2.157	<.001	<.001	3	4
SKCM	SGO2 →	+1.034	+2.913	<.001	.001	3	4
SKCM	GRPEL2 →	+0.649	+2.964	.002	<.001	3	4
UCEC	COX11 →	+0.432	+1.928	<.001	<.001	3	4
UCEC	C18orf54 →	+0.622	+1.906	<.001	<.001	3	4
UCEC	MEX3C →	+0.441	+1.954	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,564 associations by consensus.

SKA1 by SLC26A4 expression — UCEC

Explore this box plot interactively →