SLC26A4

Across TCGA patient cohorts, SLC26A4 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A4-associated genes across cancer lineages are ASNS, RAD51, and Annexin-1. Each is linked with SLC26A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC26A4-to-partner and partner-to-SLC26A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SLC26A4-low versus SLC26A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A4→partner) and Y-score (partner→SLC26A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.374	+1.584	<.001	.017	3	3
COAD	RAD51 →	+0.173	+2.815	.045	.036	3	2
COAD	Annexin-1 →	+0.425	+2.815	.043	.036	3	2
UCEC	MEK1 →	+0.406	+1.947	<.001	<.001	3	2
UCEC	PKC-b-II_pS660 →	-0.205	-1.263	.015	.019	3	2
UCEC	Shc_pY317 →	-0.137	-2.115	.003	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by SLC26A4 expression — UCEC

Explore this box plot interactively →