SLC26A3

Across TCGA pan-cancer cohorts, SLC26A3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SLC26A3 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SLC26A3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC26A3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

KIRP, HNSC, and LAML are the cancer types where SLC26A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.111	0.934	<.001	42	view →
HNSC	OS	Median	IV	0.051	0.643	<.001	17	view →
LAML	DFS	Median	All	0.056	0.572	.001	12	view →
READ	DFS	Median	III,IV	0.182	0.745	.007	12	view →
UCEC	DFS	Median	All	0.964	0.619	.013	10	view →
LGG	OS	Median	All	0.195	0.889	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	OS	Median	IV	0.141	0.589	.018	6	view →
LUAD	OS	Median	III,IV	0.004	0.662	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.796	0.537	.032	6	view →
SCLC	DFS	Median	All	0.265	0.634	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SLC26A3–KIRP (OS)

Open the KIRP breakdown →