SLC26A3

Across TCGA patient cohorts, SLC26A3 mutation is significantly associated with the RNA expression of many other genes, with 4,878 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A3-associated genes across cancer lineages are NFKBIB, GAPDH, and ENO1. Each is linked with SLC26A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC26A3-to-partner and partner-to-SLC26A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFKBIB grouped by SLC26A3-low versus SLC26A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A3→partner) and Y-score (partner→SLC26A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFKBIB →	+0.367	+2.202	.001	.001	3	3
UCEC	GAPDH →	+0.390	+1.502	.005	.007	3	3
UCEC	ENO1 →	+0.551	+2.700	<.001	<.001	3	3
SKCM	ATG16L1 →	+0.384	+2.970	.002	<.001	3	3
UCEC	RPL26 →	+0.554	+3.732	.001	<.001	3	3
UCEC	FEN1 →	+0.707	+2.354	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,878 associations by consensus.

NFKBIB by SLC26A3 expression — UCEC

Explore this box plot interactively →