SLC26A3

Across TCGA cell cohorts, SLC26A3 mutation is significantly associated with the RNA expression of many other genes, with 572 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC26A3-associated genes across cancer lineages are PHOX2B, HDLBP, and NSUN4. Each is linked with SLC26A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC26A3-to-partner and partner-to-SLC26A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by SLC26A3-low versus SLC26A3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A3→partner) and Y-score (partner→SLC26A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHOX2B →	+0.016	+3.687	<.001	<.001	3	2
LARGE_INTESTINE	HDLBP →	+0.537	+2.628	.003	.002	3	2
LARGE_INTESTINE	NSUN4 →	+0.548	+3.237	.003	.003	3	2
LARGE_INTESTINE	ZSCAN20 →	+0.431	+2.628	.001	.002	3	2
LARGE_INTESTINE	NAF1 →	+0.606	+3.584	.001	<.001	3	2
URINARY_TRACT	TGM7 →	+0.013	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 572 associations by consensus.

PHOX2B by SLC26A3 expression — BLOOD_Leukemia

Explore this box plot interactively →