SLC26A2

Across TCGA pan-cancer cohorts, SLC26A2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SLC26A2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC26A2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SLC26A2 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where SLC26A2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC26A2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.551	<.001	12	view →
HNSC	Male	III,IV	−1.192	<.001	12	view →
LSCC	Male	All	+0.312	<.001	6	view →
CCRCC	Male	All	+0.203	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SLC26A2–COAD

Open the COAD breakdown →