SLC26A1

Across TCGA patient cohorts, SLC26A1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and PDCD4. Each is linked with SLC26A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC26A1-to-partner and partner-to-SLC26A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SLC26A1-low versus SLC26A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A1→partner) and Y-score (partner→SLC26A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.236	-1.736	.006	.007	3	2
UCEC	eIF4E →	+0.173	+2.415	.017	.003	3	2
UCEC	PDCD4 →	-0.350	-1.440	.032	.024	3	2
UCEC	ATM →	-0.544	-2.687	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.086	-3.432	.013	.005	3	1
UCEC	eEF2 →	+0.316	+3.321	.010	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

EGFR_pY1068 by SLC26A1 expression — UCEC

Explore this box plot interactively →