SLC26A1

Across TCGA cell cohorts, SLC26A1 mutation is significantly associated with the RNA expression of many other genes, with 380 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC26A1-associated genes across cancer lineages are VRK1, PRSS54, and C19orf44. Each is linked with SLC26A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC26A1-to-partner and partner-to-SLC26A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VRK1 grouped by SLC26A1-low versus SLC26A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A1→partner) and Y-score (partner→SLC26A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VRK1 →	+0.563	+3.212	.002	.006	3	1
LARGE_INTESTINE	PRSS54 →	+0.023	+2.760	.001	.003	3	1
LARGE_INTESTINE	C19orf44 →	+0.557	+3.237	<.001	.003	3	1
LARGE_INTESTINE	CCNJ →	+0.780	+3.212	<.001	.006	3	1
LARGE_INTESTINE	MAPK8 →	+0.773	+3.385	.001	.004	3	1
LARGE_INTESTINE	NSMCE4A →	+0.570	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 380 associations by consensus.

VRK1 by SLC26A1 expression — LARGE_INTESTINE

Explore this box plot interactively →