SLC25A6

Across TCGA cell cohorts, SLC25A6 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC25A6-associated genes across cancer lineages are EBF2, HTR1B, and LMO1. Each is linked with SLC25A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A6-to-partner and partner-to-SLC25A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EBF2 grouped by SLC25A6-low versus SLC25A6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A6→partner) and Y-score (partner→SLC25A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EBF2 →	+0.211	+3.374	<.001	.005	3	2
LARGE_INTESTINE	HTR1B →	+0.061	+2.766	<.001	.005	3	1
LARGE_INTESTINE	LMO1 →	+0.214	+3.285	<.001	.007	3	1
LARGE_INTESTINE	ANO5 →	+0.676	+3.938	<.001	<.001	3	1
LARGE_INTESTINE	SPEM1 →	+0.084	+3.084	<.001	.002	3	1
LARGE_INTESTINE	FREM3 →	+0.118	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EBF2 by SLC25A6 expression — LARGE_INTESTINE

Explore this box plot interactively →