SLC25A53

Across TCGA patient cohorts, SLC25A53 mutation is significantly associated with the RNA expression of many other genes, with 1,219 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A53-associated genes across cancer lineages are OR10A5, RRAGC, and RRP8. Each is linked with SLC25A53 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A53-to-partner and partner-to-SLC25A53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A5 grouped by SLC25A53-low versus SLC25A53-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A53→partner) and Y-score (partner→SLC25A53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR10A5 →	+0.148	+4.847	<.001	.009	3	2
UCEC	RRAGC →	+0.418	+3.724	.003	<.001	3	2
UCEC	RRP8 →	+0.319	+2.425	.005	.002	3	2
UCEC	COQ3 →	+0.479	+2.425	.005	.002	3	2
CESC	YBX1P9 →	+0.081	+5.010	<.001	.009	3	2
UCEC	FANCA →	+0.616	+3.480	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,219 associations by consensus.

OR10A5 by SLC25A53 expression — SCLC

Explore this box plot interactively →