SLC25A53

Across TCGA patient cohorts, SLC25A53 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A53-associated genes across cancer lineages are MSH6, p38-MAPK_pT180_Y182, and p62 Lck ligand. Each is linked with SLC25A53 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A53-to-partner and partner-to-SLC25A53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by SLC25A53-low versus SLC25A53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A53→partner) and Y-score (partner→SLC25A53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.398	-2.321	.003	.006	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.399	-1.794	.031	.027	3	2
UCEC	p62 Lck ligand →	+0.310	+2.009	.021	.017	3	2
UCEC	VHL →	-0.763	-2.321	.006	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.734	+2.321	.002	.033	3	2
UCEC	14-3-3_beta →	-0.099	-2.301	.016	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MSH6 by SLC25A53 expression — UCEC

Explore this box plot interactively →