SLC25A52

Across TCGA patient cohorts, SLC25A52 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A52-associated genes across cancer lineages are FOXO3a_pS318_S321, ACC1, and Notch1. Each is linked with SLC25A52 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A52-to-partner and partner-to-SLC25A52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by SLC25A52-low versus SLC25A52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A52→partner) and Y-score (partner→SLC25A52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.115	-1.678	.016	.023	3	2
SKCM	ACC1 →	+0.326	+2.459	.028	.020	3	2
UCEC	Notch1 →	+0.197	+3.598	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.266	-2.584	.005	.010	3	1
UCEC	ERK2 →	+0.173	+2.584	.018	.010	3	1
UCEC	FoxM1 →	+0.226	+1.678	.022	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

FOXO3a_pS318_S321 by SLC25A52 expression — UCEC

Explore this box plot interactively →