SLC25A51

Across TCGA pan-cancer cohorts, SLC25A51 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC25A51 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC25A51 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC25A51 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where SLC25A51 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.772	.006	56	view →
CCRCC	OS	Tertile	II,III,IV	0.603	1.000	.006	23	view →
LSCC	DFS	Median	All	0.496	0.949	<.001	22	view →
PDAC	OS	Median	All	0.353	0.690	.027	2	view →
GBM	DFS	Tertile	All	0.851	0.678	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC25A51–HNSC (DFS)

Open the HNSC breakdown →