Across TCGA pan-cancer cohorts, SLC25A48 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SLC25A48’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SLC25A48 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SLC25A48 is over-expressed in tumor.
LSCC and LUAD are the cancer types where SLC25A48 tumor–normal differential expression is most reproducible.