SLC25A46

Across TCGA pan-cancer cohorts, SLC25A46 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SLC25A46 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC25A46 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC25A46 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where SLC25A46 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	IV	0.260	0.887	.024	11	view →
HNSC	OS	Median	II,III,IV	0.821	0.634	.013	10	view →
LSCC	DFS	Median	All	0.609	0.803	.020	10	view →
GBM	DFS	Median	All	0.253	0.467	.015	4	view →
LUAD	OS	Quartile	III,IV	0.821	0.386	.016	2	view →
PDAC	DFS	Tertile	III,IV	0.583	0.274	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SLC25A46–CCRCC (DFS)

Open the CCRCC breakdown →