SLC25A46

Across TCGA patient cohorts, SLC25A46 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A46-associated genes across cancer lineages are Src_pY527, INPP4B, and p27_pT198. Each is linked with SLC25A46 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC25A46-to-partner and partner-to-SLC25A46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by SLC25A46-low versus SLC25A46-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A46→partner) and Y-score (partner→SLC25A46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.418	-3.449	.018	.005	3	3
UCEC	INPP4B →	-0.364	-2.308	.006	.006	3	2
UCEC	p27_pT198 →	+0.098	+1.807	.027	.027	3	2
UCEC	PRDX1 →	+0.178	+2.321	.036	.034	3	2
UCEC	EGFR_pY1068 →	-0.235	-1.807	.023	.027	3	1
UCEC	eIF4G →	+0.344	+3.459	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Src_pY527 by SLC25A46 expression — UCEC

Explore this box plot interactively →