SLC25A46

Across TCGA cell cohorts, SLC25A46 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC25A46-associated genes across cancer lineages are CLPSL1, KRTAP10-2, and CHRNB3. Each is linked with SLC25A46 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A46-to-partner and partner-to-SLC25A46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPSL1 grouped by SLC25A46-low versus SLC25A46-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A46→partner) and Y-score (partner→SLC25A46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLPSL1 →	+0.116	+3.376	<.001	.002	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.044	+2.994	.001	.006	3	1
STOMACH	CHRNB3 →	+0.010	+4.285	<.001	.007	3	1
STOMACH	OR1D5 →	+0.017	+4.285	<.001	.007	3	1
BLOOD_Lymphoma	CLCN1 →	+0.028	+4.058	<.001	.009	2	1
LARGE_INTESTINE	REELD1 →	+0.092	+3.333	.004	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CLPSL1 by SLC25A46 expression — LARGE_INTESTINE

Explore this box plot interactively →