SLC25A43

Across TCGA pan-cancer cohorts, SLC25A43 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SLC25A43’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SLC25A43 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC25A43 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where SLC25A43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.254	<.001	12	view →
LIHC	Male	II,III,IV	+1.371	<.001	9	view →
HNSC	All	All	+0.603	.001	8	view →
BLCA	Male	All	+1.135	<.001	6	view →
STAD	All	III,IV	+0.893	.009	6	view →
BRCA	All	II,III,IV	+0.309	<.001	6	view →
KICH	Female	All	−1.396	<.001	5	view →
LUSC	Male	II,III,IV	+0.847	<.001	5	view →
THCA	All	All	−0.301	.003	4	view →
PAAD	Male	All	+0.280	.010	4	view →
CHOL	All	All	+1.663	<.001	3	view →
ESCA	All	All	+1.157	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SLC25A43–KIRC

Open the KIRC breakdown →