SLC25A40

Across TCGA pan-cancer cohorts, SLC25A40 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC25A40 data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC25A40 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC25A40 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where SLC25A40 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.640	0.865	.013	12	view →
LUAD	DFS	Tertile	III,IV	0.790	0.210	.008	11	view →
LSCC	DFS	Tertile	All	0.695	0.935	.009	9	view →
PDAC	OS	Median	IV	0.231	0.929	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC25A40–CCRCC (DFS)

Open the CCRCC breakdown →