SLC25A4

Across TCGA pan-cancer cohorts, SLC25A4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC25A4 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SLC25A4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SLC25A4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where SLC25A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.801	0.504	.044	2	view →
CCRCC	DFS	Quartile	All	1.000	0.503	.012	2	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →
GBM	DFS	Median	All	0.821	0.679	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC25A4–LUAD (OS)

Open the LUAD breakdown →