SLC25A4

Across TCGA patient cohorts, SLC25A4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A4-associated genes across cancer lineages are EGFR, FoxM1, and PDCD4. Each is linked with SLC25A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A4-to-partner and partner-to-SLC25A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by SLC25A4-low versus SLC25A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A4→partner) and Y-score (partner→SLC25A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.261	-2.459	<.001	.020	3	1
UCEC	FoxM1 →	+0.263	+3.584	.035	.002	3	1
UCEC	PDCD4 →	-0.467	-2.459	.040	.020	3	1
UCEC	CD49b →	-0.343	-2.986	.012	.035	3	1
UCEC	VHL →	-1.072	-3.584	.001	.002	2	1
UCEC	Caspase-8 →	-0.275	-3.584	.023	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR by SLC25A4 expression — UCEC

Explore this box plot interactively →