SLC25A35

Across TCGA patient cohorts, SLC25A35 mutation is significantly associated with the RNA expression of many other genes, with 271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A35-associated genes across cancer lineages are CTLA4, RNU4-45P, and RNU6-207P. Each is linked with SLC25A35 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A35-to-partner and partner-to-SLC25A35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTLA4 grouped by SLC25A35-low versus SLC25A35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A35→partner) and Y-score (partner→SLC25A35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTLA4 →	+0.734	+3.475	.008	.002	3	2
CESC	RNU4-45P →	+0.221	+5.342	<.001	.002	3	2
SKCM	RNU6-207P →	+0.393	+5.199	<.001	.003	3	2
COAD	MIR190A →	+0.211	+4.332	<.001	.006	3	2
UCEC	KLRD1 →	+0.354	+3.807	.002	<.001	3	2
UCEC	MIR520H →	+0.237	+3.582	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 271 associations by consensus.

CTLA4 by SLC25A35 expression — UCEC

Explore this box plot interactively →