SLC25A34

Across TCGA pan-cancer cohorts, SLC25A34 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC25A34’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC25A34 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC25A34 is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and KICH are the cancer types where SLC25A34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.352	<.001	12	view →
KIRP	All	IV	−2.955	<.001	11	view →
KICH	Male	III,IV	−3.060	<.001	10	view →
LUAD	All	III,IV	−0.648	<.001	9	view →
HNSC	Male	All	−1.550	<.001	8	view →
THCA	All	All	−0.503	<.001	8	view →
READ	All	II,III,IV	−2.437	<.001	7	view →
BRCA	All	III,IV	−0.868	<.001	6	view →
LUSC	All	II,III,IV	−0.562	<.001	6	view →
UCEC	All	II,III,IV	−0.578	.024	4	view →
KIRC	Male	All	−0.620	.001	3	view →
BLCA	Male	IV	−0.669	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC25A34–COAD

Open the COAD breakdown →