SLC25A32

Across TCGA pan-cancer cohorts, SLC25A32 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC25A32’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC25A32 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC25A32 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and STAD are the cancer types where SLC25A32 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A32 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.233	<.001	12	view →
COAD	All	III,IV	+1.163	<.001	11	view →
STAD	Male	II,III,IV	+1.270	<.001	8	view →
THCA	Female	All	−0.506	<.001	7	view →
LIHC	Male	II,III,IV	+0.809	<.001	6	view →
KIRC	All	All	+0.232	<.001	6	view →
READ	All	All	+0.926	.004	4	view →
LUSC	Male	All	+0.418	<.001	4	view →
BRCA	All	II,III,IV	+0.389	<.001	4	view →
KICH	Female	All	−0.871	<.001	3	view →
LUAD	Male	All	+0.385	.016	3	view →
ESCA	All	All	+1.280	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC25A32–HNSC

Open the HNSC breakdown →